It is always a matter of finding the appropriate moment.
Latest step of my let-me-get-rid-of-some-commitments-and-then-figure-out-what-I-really-want-to-do-with-my-life: I simply left the ESMO system engineering team the other day - meaning that I am currently not in Noordwijk, NL, attending the workshop running this week and I am not going to be around now when ESMO has officially moved from Phase A into Phase B1. Best wishes to the ones staying within the project, thank you for the good and the bad times we all shared. Take good care of the "baby".
For me it is time to move on now.